Fig. 3. Comparison of similarity of HMA animal fecal bacterial communities and corresponding human donor bacterial communities.

(a) Unweighted UniFrac distances and (b) Bray–Curtis distances. The box represents the 25th and 75th percentiles as the interquartile range (IQR) and the short black line represents the median. The whiskers represent the minimum and maximum values. Outliers are shown as black dots. Statistical comparisons were performed using the Wilcoxon rank-sum test. ***p < 1 × 10⁻⁵; ****p < 1 × 10⁻¹⁰; ns–not significant. n = 13 (3 piglets/donor, with the exception n = 4 for Donor_1, 2 days post inoculation) and n = 37 mice (Donor_1 = 7, Donor_2 = 10, Donor_3 = 10, Donor_4 = 10).