Table 7.
Enriched and depleted gene sets associated with cardiac function, cardiovascular disease, and angiogenesis.
| Category | Subcategory | P value | Number of miRNAs |
|---|---|---|---|
| Enriched gene sets | |||
| Gene Ontology | GO0001525 angiogenesis | 0.026 | 105 |
| Gene Ontology | GO0045765 regulation of angiogenesis | 0.037 | 31 |
| Gene Ontology | GO0019722 calcium mediated signaling | 0.040 | 30 |
| Gene Ontology | GO0030168 platelet activation | 0.031 | 120 |
| Gene Ontology | GO0090330 regulation of platelet aggregation | 0.049 | 5 |
| Gene Ontology | GO0055008 cardiac muscle tissue morphogenesis | 0.038 | 10 |
| Gene Ontology | GO0055015 ventricular cardiac muscle cell development | 0.004 | 13 |
| Gene Ontology | GO0055008 cardiac muscle tissue morphogenesis | 0.038 | 10 |
| Gene Ontology | GO0010460 positive regulation of heart rate | 0.044 | 10 |
| Gene Ontology | GO0060047 heart contraction | 0.038 | 11 |
| WikiPathways | WP1559 TFs Regulate miRNAs related to cardiac hypertrophy | 0.048 | 24 |
| KEGG | hsa05412 Arrhythmogenic right ventricular cardiomyopathy ARVC | 0.034 | 62 |
| KEGG | hsa05416 Viral myocarditis | 0.012 | 80 |
| Depleted gene sets | |||
| Gene Ontology | GO2000727 positive regulation of cardiac muscle cell differentiation | 0.024 | 17 |
| Gene Ontology | GO0090050 positive regulation of cell migration involved in sprouting angiogenesis | 0.041 | 33 |
| Gene Ontology | GO0001946 lymphangiogenesis | 0.033 | 26 |