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. 2020 Dec 12;11(12):1060. doi: 10.1038/s41419-020-03282-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A TCGA (TNBC: 115; non-TNBC: 858) and GSE2603 (TNBC: 25; non-TNBC: 71) databases were interrogated for FZD5 expression. FZD5 mRNA levels were compared between TNBC and non-TNBC. **P < 0.01, ***P < 0.001, vs. non-TNBC. B FZD5 expression in 18 TNBC and 24 non-TNBC was detected by immunohistochemistry. Staining of some representative samples was shown. H: high; M: median; L: low; N: negative. Scalebar: 25 μm. C The association of FZD5 with OS, RFS, DMFS, and PPS was analyzed in Kaplan–Meier plotter website. D, E Go analysis of the gene pathways differentially expressed between FZD5-high and FZD5-low breast cancer samples in TCGA database was performed. Four representative GSEA-enrichment plots were shown.