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. 2020 Dec 12;11(12):1060. doi: 10.1038/s41419-020-03282-3

Fig. 4. FZD5 enhances DNA damage repair and chemoresistance.

Fig. 4

A γ-H2AX expression in MDA-MB-231 cells was detected by immunofluorescence 48 h after treatment with ADR (300 nM). Scale bar: 100 μm. B EXO1, PLK4, and RFC4 expression in MDA-MB-231 cells was detected by real-time PCR, mean±SD, n = 3. **P < 0.01, ***P < 0.001, vs shCtrl. C Death of MDA-MB-231 cells was detected by flow cytometry 48 h after treatment with ADR (300 nM). D γ-H2AX expression in Hs-578t cells was detected by immunofluorescence 48 h after treatment with ADR (300 nM). Scale bar: 100 μm. E EXO1, PLK4, and RFC4 expression in Hs-578t cells was detected by real-time PCR, mean ± SD, n = 3. ***P < 0.001, vs. OE Ctrl. F Death of Hs-578t cells was detected by flow cytometry 48 h after treatment with ADR (300 nM).