Skip to main content
. 2020 Dec 11;477(23):4603–4621. doi: 10.1042/BCJ20200506

Figure 2. Reported regulators of CK1.

Figure 2.

(A) CG-NAP localises CK1δ and ɛ to centrosomes. (B) CK1ɛ is sequestered and bound by Axin, which competes with Dvl for CK1ɛ binding. Following Wnt stimulation, CK1ɛ dissociates from Axin and binds to DDX3. DDX3 increases the catalytic activity of CK1ɛ to facilitate the phosphorylation of Dvl by CK1ɛ. (C) The FAM83 family of proteins co-ordinate the localisation of distinct subsets of CK1 isoforms to various subcellular sites as shown. A question mark (?) denotes cases where the physiological function of the FAM83–CK1 interaction is still to be determined.