Table 3.
Race/Ethnicity-Specific Association of Periodontal Disease and Edentulism with Total Cancer Mortality, 6,034 Participants ≥40 Years Old in NHANES IIIa
| Race specific | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-Hispanic White | Non-Hispanic Black | Mexican-American | |||||||
| Cases | Person-years | HR (95% CI) | Cases | Person-years | HR (95% CI) | Cases | Person-years | HR (95% CI) | |
| Model 1b | |||||||||
| Periodontitis (NHANES) | |||||||||
| No | 174 | 33497 | 1 (ref) | 93 | 16661 | 1 (ref) | 78 | 17633 | 1 (ref) |
| Yes | 43 | 6498 | 1.08 (0.72, 1.64) | 60 | 7643 | 1.26 (0.85, 1.86) | 44 | 5467 | 1.45 (0.97, 2.18) |
| Edentulism | 112 | 8255 | 1.87 (1.34, 2.61) | 54 | 4047 | 1.83 (1.20, 2.78) | 27 | 1706 | 2.04 (1.00, 4.19) |
| Periodontitis (CDC/AAP) | |||||||||
| No | 163 | 33037 | 1 (ref) | 79 | 17064 | 1 (ref) | 68 | 17289 | 1 (ref) |
| Mild | 6 | 1009 | 0.86 (0.38, 1.95) | 5 | 1192 | 0.75 (0.34, 1.63) | 3 | 637 | 0.74 (0.18, 3.06) |
| Moderate | 39 | 5053 | 1.23 (0.76, 1.98) | 50 | 4693 | 1.62 (1.08, 2.44) | 43 | 4315 | 1.82 (1.19, 2.80) |
| Severe | 9 | 896 | 1.96 (0.77, 4.99) | 19 | 1355 | 2.40 (1.20, 4.81) | 8 | 858 | 1.48 (0.54, 4.06) |
| P-trend | 0.17 | 0.01 | 0.03 | ||||||
| Edentulism | 112 | 8255 | 1.94 (1.39, 2.71) | 54 | 4047 | 2.09 (1.29, 3.40) | 27 | 1706 | 2.30 (1.07, 4.96) |
| Model 2c | |||||||||
| Periodontitis (NHANES) | |||||||||
| No | 174 | 33497 | 1 (ref) | 93 | 16661 | 1 (ref) | 78 | 17633 | 1 (ref) |
| Yes | 43 | 6498 | 0.93 (0.62, 1.39) | 60 | 7643 | 1.23 (0.82, 1.85) | 44 | 5467 | 1.34 (0.85, 2.11) |
| Edentulism | 112 | 8255 | 1.50 (1.09, 2.05) | 54 | 4047 | 1.60 (1.05, 2.43) | 27 | 1706 | 1.96 (0.99, 3.88) |
| Periodontitis (CDC/AAP) | |||||||||
| No | 163 | 33037 | 1 (ref) | 79 | 17064 | 1 (ref) | 68 | 17289 | 1 (ref) |
| Mild | 6 | 1009 | 0.84 (0.37, 1.90) | 5 | 1192 | 0.79 (0.37, 1.70) | 3 | 637 | 0.72 (0.18, 2.81) |
| Moderate | 39 | 5053 | 0.96 (0.59, 1.54) | 50 | 4693 | 1.39 (0.92, 2.11) | 43 | 4315 | 1.67 (1.00, 2.79) |
| Severe | 9 | 896 | 1.40 (0.53, 3.68) | 19 | 1355 | 1.97 (0.93, 4.15) | 8 | 858 | 1.30 (0.37, 4.55) |
| P-trend | 0.71 | 0.09 | 0.13 | ||||||
| Edentulism | 112 | 8255 | 1.52 (1.11, 2.09) | 54 | 4047 | 1.74 (1.06, 2.86) | 27 | 1706 | 2.16 (1.02, 4.59) |
| Model 3d | |||||||||
| Periodontitis (NHANES) | |||||||||
| No | 174 | 33497 | 1 (ref) | 93 | 16661 | 1 (ref) | 78 | 17633 | 1 (ref) |
| Yes | 43 | 6498 | 0.94 (0.62, 1.40) | 60 | 7643 | 1.20 (0.81, 1.80) | 44 | 5467 | 1.23 (0.79, 1.94) |
| Edentulism | 112 | 8255 | 1.51 (1.08, 2.13) | 54 | 4047 | 1.53 (1.00, 2.33) | 27 | 1706 | 1.90 (0.91, 3.98) |
| Periodontitis (CDC/AAP) | |||||||||
| No | 163 | 33037 | 1 (ref) | 79 | 17064 | 1 (ref) | 68 | 17289 | 1 (ref) |
| Mild | 6 | 1009 | 0.83 (0.35, 1.94) | 5 | 1192 | 0.71 (0.32, 1.59) | 3 | 637 | 0.71 (0.10, 2.65) |
| Moderate | 39 | 5053 | 0.95 (0.58, 1.57) | 50 | 4693 | 1.40 (0.94, 2.10) | 43 | 4315 | 1.48 (0.84, 2.62) |
| Severe | 9 | 896 | 1.41 (0.52, 3.87) | 19 | 1355 | 1.92 (0.92, 3.98) | 8 | 858 | 1.12 (0.33, 3.78) |
| P-trend | 0.71 | 0.11 | 0.28 | ||||||
| Edentulism | 112 | 8255 | 1.54 (1.08, 2.19) | 54 | 4047 | 1.68 (1.03, 2.74) | 27 | 1706 | 2.04 (0.90, 4.64) |
HR = hazard ratio, CI = confidence interval, CDC/AAP = Centers for Disease Control/American Academy of Periodontology
Model 1 adjusted for age in years (continuous), and sex (males and females).
Model 2 adjusted for age in years (continuous), sex (males and females), body mass index (continuous), pack years (continuous), smoking status (never, former, current), and diabetes (non-diabetic, pre-diabetic, diabetic).
Model 3 adjusted for age in years (continuous), sex (males and females), body mass index (continuous), pack years (continuous), smoking status (never, former, current), diabetes (non-diabetic, pre-diabetic, diabetic), education (<high school, high school, >high school), annual family income (<$25000, $25000-$74999, >$74999), and health insurance (covered and not covered).