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. 2020 Nov 23;117(49):31353–31364. doi: 10.1073/pnas.2011614117

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Copyright © 2020 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 5. — MCB-613 promotes long-lasting fibroblast differentiation and enrichment of Cbr2 macrophages. (A) χ² cluster composition analysis of subclustered fibroblasts 12 wk post-MI (Left). UMAP plot of fibroblast subclusters (Right). (B) Heat map showing top differentially expressed genes. (C) Pseudotime trajectory and corresponding density ridge plot across the pseudotime trajectory colored according to cluster identity (Top). Heatmap showing dynamics of gene expression for fibroblasts across the trajectory (Bottom). (D) The χ² cluster composition analysis of subclustered fibroblasts across the trajectory. Density ridge plot according to treatment condition. (E) GO terms analysis of differentially expressed genes from fibroblasts in control compared to MCB-613. (F) UMAP plot of macrophage subclusters 12 wk post-MI. (G) The χ² cluster composition analysis of subclustered macrophages from MCB-613 compared to control 12 wk post-MI. (H) Cbr2 expression feature plot.