Fig. 8.

Comparison of coclassification difference matrices for female and male FB2 networks and for intact vs. Alzheimer’s lesion or depression lesion. In all panels, positive differences (displayed in blue) indicate greater coclassification in the first (minuend) over the second (subtrahend) matrix element. To allow comparison, all difference matrices are displayed in the same canonical FB2f ordering scheme (Fig. 2). (A) As a control (A, 1), the original FB2f matrix (Fig. 2, third column) was run twice (each with 2.5 million uniformly sampled partitions); negligible differences were found between the two replicates (for quantification, see SI Appendix, Table S1). The 99th percentile of differences between these replicates was taken as a significance threshold, applied to all other comparisons between sexes and lesions (below-threshold differences are discarded). (A, 2) Coclassification differences obtained by subtracting male matrix from female matrix. (B) Effects of ENTl-PERI numerical lesions (in SS1 and SS2) in the female (B, 1) and a comparison with the effects in male (B, 2). The index plotted in B, 1, expresses the change in a region pair’s coclassification that may be higher in the intact (blue) or higher in the lesioned (red) network configuration; the sex difference index for B, 2, corresponds to that for A, 2. (C) Effects of ILA numerical lesions (in SS1 and SS2) in the female (C, 1) and a comparison with the effects in male (C, 2). Coclassification index measures correspond to those shown in B, 1, and B, 2. For the intact FB2f and FB2m coclassification matrices and associated subsystem hierarchies, see Figs. 2, 5, and 6; SI Appendix, Fig. S3 C–E; and Dataset S4. For quantitation of matrix differences, see SI Appendix, Table S1.