Figure 6.
Analysis of Transcriptional Responses of Human Dermal Fibroblasts to a Double-Stranded RNA Stimulus
(A) Illustration of experimental design and tested mechanism of transcriptional responses.58
(B) t-SNE plot of human dermal fibroblasts before (blue) and after (red) dsRNA stimulus.
(C) Violin plots showing the log-normalized expression levels of selected differentially regulated genes before (blue) and after (red) stimulus.
(D) Q-Q plot for observed and expected p values of tested genes. Genes (n = 29) with FDR <0.05 are labeled with an asterisk. Inset shows the results of GSEA for genes ranked by their distances in manifold aligned scGRNs.
(E) Comparison of a representative module that contains three differentially regulated genes in the control sample. The colors, edges, and marks are presented as in Figure 3E.
(F) Scatterplots showing the correlation between TPT1 and ANXA2 before (top) and after (bottom) dsRNA stimulus.