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. 2020 Nov 5;1(9):100139. doi: 10.1016/j.patter.2020.100139

Table 1.

Summary of Real-Data Applications of scTenifoldNet Analysis

Study Reference Species Cell Type Perturbation Type Number of Genes Included in Analysis Number of Cells in Two Groups Number of Differentially Regulated Genes Enriched Functions of Differentially Regulated Genes
1 Avey et al.36 mouse neurons morphine 8,138 mock-treated 8,912; morphine-treated, 7,972 56 opioid signaling; signaling by G-protein-coupled receptors; reduction of cytosolic calcium levels; morphine addiction
2 Kagohara et al.48 human carcinoma cell line cetuximab 11,140 untreated, 5,217; treated, 4,507 125 EGFR1 pathway; regulation of apoptosis; cell-cycle checkpoints; G1 cell-cycle arrest, regulation of apoptosis
3 Little et al.54 mouse lung alveolar cells Nkx2-1 gene KO 7,842 WT, 638; KO, 2,397 29 gastrointestinal marker genes; Sox2 target genes
4 Hagai et al.58 human dermal fibroblasts dsRNA immune stimulus 7,904 unstimulated, 2,553; stimulated, 2,130 29 interferon signaling; immune system; interleukin-1 regulation of extracellular matrix
5 Zhou et al.64 mouse neurons Alzheimer disease 2,869 WT, 4,561; 5xFAD, 2,423 18 Apoe and Bin1; regulation of neuron projection development; positive regulation of cell projection organization; phosphatidylserine metabolic process; protein acylation; potassium channel activity; methylation-dependent protein binding; integrin signaling pathway; serotonin HTR1 group and FOS pathway; glutamate neurotransmitter release cycle