Fig. 1.

Phenotype level representation of the AIR. The landscape of acute inflammatory response is divided into four overlapping phases: Initiation, transition, resolution and return to tissue homeostasis. Interactions between immune cell types, vascular endothelial cells, mucosal epithelial cells as well as the associated processes and phenotypes are depicted. Arrows indicate information flow. The color of arrows indicates regulation type; gray for activation and red for inhibition. Each process is connected with underlying manually curated and annotated molecular interaction maps. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)