Fig. 3.

Acute inflammation and inflammation resolution follows the concept of Mesarovic's Interaction Balance Coordination Principle. Two subprocesses (neutrophil dynamics and macrophage dynamics) are controlled by their respective miRNA, cytokines and transcription factors (TF). These subprocesses communicate together in the regulation of phenotype. If there is any imbalance in the desired and actual outputs by these processes (shown by ‘+’ sign, higher level coordination layer (shown here by ‘SPM Production’, ‘Lipid Mediator Switching’) provide signals and make the balance between subprocesses to return to homeostasis. The AIR provides molecular level details of these coordination layers and offers an opportunity to harness these layers for therapeutic purposes.