Fig. 5.

Mapping of time-series data onto the AIR. Nodes are overlaid with colored bars where each bar indicates the data at a given time point. In this example, log2 concentration fold change values of selected SPM were calculated at 4 time points (0 h, 12 h, 24 h and 48 h) and mapped onto the AIR when mice were challenged with higher titre E. coli (10⁷ c.f.u.) compared to self-resolving E. coli infection (10⁵ c.f.u.) (Chiang et al., 2012). The color gradient from red to blue indicates downregulation and upregulation. The color bars demonstrate that all the pro-inflammatory lipid mediators (PGE2, 5 S-HETE and LTB4) are mostly upregulated from time point 0 h–48 h in response to the stimulus. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)