Table 2.
Summary of Ktrans, kGad, test-retest averaged kw values, and regression coefficients of mixed-effect linear regressions between Ktrans/kGad and test-retest kw in the whole brain, gray matter, white matter, and six subcortical brain regions.
| kw (min−1) | BBB permeability to contrast agent | Vp (%) | CBF (ml/100g/min) | ATT (ms) | ||||
|---|---|---|---|---|---|---|---|---|
| Ktrans (×10−4 min−1) | β: kw ~ Ktrans (P-value) | kGad (×10−2 min−1) | β: kw ~ kGad (P-value) | |||||
| Whole brain | 122.3 ± 16.5 | 6.6 ± 0.7 | 6.5 × 104 (0.19) | 1.9 ± 0.3 | 0.9 × 103 (0.42) | 3.5 ± 0.6 | 43.9 ± 5.1 | 1188.5 ± 113.1 |
| Gray matter | 122.6 ± 15.6 | 6.8 ± 0.7† | 2.4 × 104 (0.65) | 1.6 ± 0.2† | 0.8 × 103 (0.54) | 4.2 ± 0.7 | 44.8 ± 5.2 | 1183.0 ± 115.1 |
| White matter | 121.9 ± 17.2 | 6.1 ± 1.1† | 6.7 × 104 (0.036)* | 3.3 ± 0.7† | 0.1 × 103 (0.81) | 1.9 ± 0.5 | 37.2 ± 4.4 | 1230.7 ± 106.6 |
| MCA perf | 126.2 ± 21.5 | 6.3 ± 1.6 | 6.9 × 104 (0.009)* | 2.2 ± 0.6† | 1.5 × 103 (0.049)* | 2.9 ± 0.8 | 40.0 ± 5.0 | 1231.8 ± 111.2 |
| Caudate | 124.6 ± 25.6 | 5.7 ± 1.3† | 8.6 × 104 (0.029)* | 2.1 ± 0.6 | 1.4 × 103 (0.14) | 2.9 ± 0.9 | 30.4 ± 3.8 | 1155.4 ± 129.0 |
| MTL | 125.3 ± 19.8 | 6.9 ± 1.0 | 1.0 × 104 (0.81) | 1.3 ± 0.2† | 3.5 × 103 (0.032)* | 5.2 ± 0.6 | 38.5 ± 4.0 | 1187.5 ± 108.1 |
| Amygdala | 133.4 ± 24.8† | 6.5 ± 1.6 | −0.8 × 104 (0.98) | 1.2 ± 0.4† | 1.6 × 103 (0.25) | 5.5 ± 1.4 | 41.0 ± 4.9 | 1234.0 ± 134.2 |
| Hippocampus | 124.7 ± 19.9 | 7.6 ± 1.2† | 3.1 × 104 (0.32) | 1.1 ± 0.2† | 3.4 × 103 (0.038)* | 6.6 ± 0.9 | 38.9 ± 4.1 | 1197.7 ± 116.5 |
| PHG | 123.9 ± 20.5 | 6.4 ± 0.9 | −3.1 × 104 (0.48) | 1.7 ± 0.3† | 2.4 × 103 (0.08) | 3.9 ± 0.5 | 37.7 ± 3.8 | 1167.6 ± 104.6 |
Vp and test-retest averaged CBF and ATT values were also listed. Daggers (†) indicate the brain regions with significantly different Ktrans, kGad or test/retest averaged kw than whole-brain average. P-values of mixed-effect linear regressions were listed in the parentheses. Significant correlations with P < 0.05 were marked by asterisks (*).
MCA perf, middle cerebral artery perforator territory; MTL, medial-temporal lobe; PHG, parahippocampal gyrus; ICC, intraclass correlation coefficient.