Table 5.
Summary of average, SD and spread (SD/average) of Ktrans, kGad and kw values in multiple WMHs (top) and WMH penumbras (bottom).
| Ktrans, kGad and kw in multiple WMHs | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subject # | Number of WMHs | Ktrans (10−4 min−1) | kGad (10−2 min−1) | kw (min−1) | ||||||
| Average | SD | SD/average | Average | SD | SD/average | Average | SD | SD/average | ||
| 1 | 36 | 8.0 | 4.2 | 0.52 | 6.3 | 6.2 | 0.98 | 148.3 | 15.8 | 0.11 |
| 2 | 6 | 5.8 | 6.0 | 1.04 | 3.4 | 2.5 | 0.74 | 147.9 | 20.6 | 0.14 |
| 3 | 3 | 3.7 | 5.9 | 1.61 | 4.4 | 2.5 | 0.57 | 135.1 | 18.8 | 0.14 |
| 4 | 8 | 2.5 | 0.4 | 0.17 | 1.6 | 1.3 | 0.81 | 108.6 | 19.8 | 0.18 |
| 5 | 23 | 6.3 | 2.3 | 0.36 | 8.0 | 8.4 | 1.05 | 151.3 | 34.9 | 0.23 |
| 6 | 23 | 5.6 | 4.3 | 0.77 | 5.9 | 7.2 | 1.22 | 133.1 | 19.8 | 0.15 |
| 7 | 4 | 4.9 | 3.4 | 0.69 | 3.4 | 3.0 | 0.88 | 73.2 | 38.8 | 0.53 |
| 8 | 11 | 4.8 | 3.8 | 0.78 | 2.0 | 1.6 | 0.80 | 119.6 | 15.4 | 0.13 |
| Ktrans, kGad and kw in multiple WMH penumbras | ||||||||||
| Subject # | Number of WMH penumbras | Ktrans (10−4 min−1) | kGad (10−2 min−1) | kw (min−1) | ||||||
| Average | SD | SD/average | Average | SD | SD/average | Average | SD | SD/average | ||
| 1 | 19 | 8.6 | 3.5 | 0.41 | 4.7 | 1.9 | 0.40 | 146.2 | 13.5 | 0.09 |
| 2 | 3 | 6.8 | 3.2 | 0.47 | 4.6 | 0.9 | 0.20 | 148.9 | 16.9 | 0.11 |
| 3 | 3 | 5.9 | 4.6 | 0.78 | 11.4 | 7.1 | 0.62 | 134.5 | 22.6 | 0.17 |
| 4 | 8 | 5.0 | 2.6 | 0.53 | 3.3 | 1.5 | 0.45 | 107.2 | 18.1 | 0.17 |
| 5 | 15 | 5.8 | 2.8 | 0.49 | 4.8 | 2.7 | 0.56 | 150.2 | 30.8 | 0.21 |
| 6 | 13 | 4.8 | 3.1 | 0.64 | 5.6 | 6.4 | 1.14 | 134.9 | 11.6 | 0.09 |
| 7 | 4 | 5.3 | 1.3 | 0.24 | 5.5 | 1.1 | 0.20 | 74.7 | 30.3 | 0.41 |
| 8 | 11 | 3.7 | 3.4 | 0.93 | 3.4 | 2.5 | 0.74 | 121.9 | 23.3 | 0.19 |
Eight subjects had more than one WMHs and WMH penumbras. Number of WMHs and WMH penumbras identified from each subject's FLAIR image were listed in the second column. Number of WMH penumbras may be smaller than number of WMHs because two or more WMH lesions can be surrounded by the same penumbra. Average value was calculated from all WMHs or penumbras, and SD was calculated as the standard deviation of Ktrans/kGad/kw values averaged in each WMH/penumbra (SD/average can be <1). Ktrans and kGad had larger spread across WMH and WMH penumbras. Average spread of Ktrans, kGad, and kw across multiple WMHs were 74.3 ± 44.2%, 88.1 ± 20.1%, and 20.2 ± 13.8%; Average spread of Ktrans, kGad, and kw between multiple WMH penumbras were 56.1 ± 21.7%, 54.0 ± 30.9%, and 17.9 ± 10.2%, respectively.
SD, standard deviation.