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. 2020 Nov 30;11:601316. doi: 10.3389/fpls.2020.601316

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Copyright © 2020 Zhu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory effects of four flavan-3-ol-gallates, four flavan-3-ol aglycones, procyanidin A2 (PA2), and procyanidin B2 (PB2) on the M^pro activity of SARS-COv-2. Inhibitory curves show that (+)-catechin-3-O-gallate (CAG) (A), (–)-epicatechin-3-O-gallate (ECG) (B), (–)-gallocatechin-3-O-gallate (GCG) (C), (–)-epigallocatechin-3-O-gallate (EGCG) (D), and PB2 (E) inhibit the activity of M^pro with an IC₅₀ 2.98 ± 0.21 μM, IC₅₀ 5.21 ± 0.5 μM, IC₅₀ 6.38 ± 0.5 μM, IC₅₀ 7.51 ± 0.21 μM, and IC₅₀ 75.31 ± 1.29 μM, respectively. (F) Inhibitory effects of 100 μM (–)-epicatechin (EC), (+)-catechin (CA), EGC, CAG, ECG, GCG, EGCG, PA2, and PB2 on the activity of M^pro. Compared with the negative control, the activity of M^pro is inhibited by 40, 40, 44.4, 50, 81.5, and 100% by 100 μM CAG, ECG, EGCG, GCG, PB2, and positive control GC376. 95% CI: 95% confidence internal and (value 1, value 2): values in the range with 95% CI.