Table 2.
Hazard ratios with 95% confidence interval for cancer and non-cancer deaths, without and with adjustment for baseline levels of potential confounders and mediators.
| Level of adjustment | Cause-Specific Hazard Model | Subdistribution Hazard Model | ||
|---|---|---|---|---|
| Cancer death | Non-cancer death | Cancer death | Non-cancer death | |
| Education | 1.56 (0.61–3.95) | 0.38 (0.20–0.73) | 1.57 (0.62–4.01) | 0.38 (0.20–0.72) |
| + basic adjustment | 1.79 (0.71–4.55) | 0.42 (0.22–0.80) | 1.80 (0.70–4.61) | 0.41 (0.21–0.80) |
| Marital status | 0.60 (0.32–1.12) | 0.60 (0.29–1.23) | 0.60 (0.32–1.13) | 0.60 (0.28–1.27) |
| + basic adjustment | 0.73 (0.38–1.39) | 0.67 (0.32–1.38) | 0.73 (0.38–1.41) | 0.67 (0.32–1.39) |
| Professional activity | 0.37 (0.20–0.67) | 0.37 (0.19–0.71) | 0.37 (0.20–0.69) | 0.37 (0.20–0.70) |
| + basic adjustment | 0.70 (0.35–1.39) | 0.41 (0.20–0.86) | 0.70 (0.36–1.38) | 0.42 (0.20–0.86) |
| BMI | 0.96 (0.71–1.29) | 1.42 (1.06–1.90) | 0.95 (0.70–1.30) | 1.42 (1.04–1.95) |
| + basic adjustment | 0.89 (0.66–1.22) | 1.39 (1.03–1.88) | 0.89 (0.64–1.24) | 1.39 (1.02–1.91) |
| Waist circumference | 0.98 (0.71–1.36) | 1.54 (1.11–2.14) | 0.98 (0.69–1.38) | 1.54 (1.08–2.19) |
| + basic adjustment | 0.86 (0.61–1.21) | 1.46 (1.05–2.05) | 0.86 (0.60–1.23) | 1.46 (1.03–2.09) |
| Waist-to-hip ratio | 1.00 (0.69–1.45) | 1.48 (1.01–2.18) | 0.99 (0.71–1.39) | 1.48 (1.09–2.02) |
| + basic adjustment | 0.80 (0.54–1.18) | 1.35 (0.90–2.02) | 0.80 (0.56–1.14) | 1.35 (0.96–1.91) |
| Waist-to-height ratio | 1.04 (0.77–1.39) | 1.59 (1.18–2.13) | 1.03 (0.77–1.39) | 1.59 (1.14–2.20) |
| + basic adjustment | 0.87 (0.64–1.20) | 1.51 (1.11–2.06) | 0.87 (0.63–1.21) | 1.51 (1.08–2.11) |
| Systolic blood pressure | 1.08 (0.82–1.44) | 1.53 (1.16–2.02) | 1.08 (0.84–1.39) | 1.53 (1.17–2.00) |
| + basic adjustment | 0.98 (0.73–1.31) | 1.45 (1.10–1.92) | 0.98 (0.75–1.27) | 1.45 (1.12–1.88) |
| Diastolic blood pressure | 1.16 (0.87–1.54) | 1.43 (1.08–1.91) | 1.15 (0.86–1.56) | 1.43 (1.10–1.87) |
| + basic adjustment | 1.22 (0.93–1.62) | 1.44 (1.09–1.89) | 1.22 (0.91–1.63) | 1.44 (1.12–1.85) |
| Glucose | 1.12 (0.92–1.37) | 1.11 (0.89–1.38) | 1.12 (1.02–1.23) | 1.11 (0.91–1.35) |
| + basic adjustment | 0.99 (0.76–1.30) | 1.00 (0.76–1.32) | 1.05 (0.94–1.17) | 1.08 (0.87–1.34) |
| Total cholesterol | 1.12 (0.85–1.49) | 1.10 (0.81–1.49) | 1.12 (0.85–1.48) | 1.10 (0.84–1.43) |
| + basic adjustment | 1.16 (0.88–1.53) | 1.14 (0.84–1.54) | 1.16 (0.88–1.51) | 1.14 (0.87–1.49) |
| HDL-C | 1.12 (0.84–1.51) | 0.93 (0.65–1.32) | 1.12 (0.84–1.49) | 0.93 (0.64–1.36) |
| + basic adjustment | 1.24 (0.92–1.66) | 0.99 (0.70–1.41) | 1.23 (0.92–1.64) | 0.99 (0.68–1.43) |
| TG | 1.08 (0.83–1.39) | 1.12 (0.89–1.42) | 1.07 (0.85–1.36) | 1.12 (0.90–1.40) |
| + basic adjustment | 1.04 (0.80–1.36) | 1.10 (0.86–1.40) | 1.52 (1.19–1.94) | 1.10 (0.88–1.37) |
| Alcochol intake | 1.00 (1.00–1.01) | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) |
| + basic adjustment | 1.00 (1.00–1.01) | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) | 1.00 (1.00–1.00) |
| Red meat intake | 1.08 (0.82–1.43) | 0.84 (0.60–1.16) | 1.08 (0.82–1.42) | 0.84 (0.59–1.18) |
| + basic adjustment | 1.13 (0.85–1.49) | 0.84 (0.61–1.17) | 1.12 (0.85–1.48) | 0.84 (0.60–1.19) |
| Familial cancer | 1.56 (0.88–2.76) | 1.07 (0.56–2.02) | 1.56 (0.88–2.76) | 1.07 (0.57–2.01) |
| + basic adjustment | 1.50 (0.84–2.66) | 1.06 (0.56–2.01) | 1.50 (0.85–2.67) | 1.06 (0.56–1.99) |
| MVPA | 0.63 (0.38–1.06) | 0.37 (0.16–0.88) | 0.63 (0.40–1.01) | 0.37 (0.18–0.77) |
| + basic adjustment | 0.72 (0.43–1.20) | 0.41 (0.17–0.96) | 0.72 (0.46–1.14) | 0.41 (0.20–0.84) |
Basic adjustment comprises age, smoking status categorised as non-smoker (never smoker and former smoker) and smoker (current smoker), and a history of diabetes, and is stratified by sex. The assumed reference categories for categorical variables: lower level of education, living single, occupationally inactive, non-smoker, negative history of diabetes, absence of familial cancer, and absence of comorbidities. BMI, body mass index; HDL-C, high density lipoprotein cholesterol; TG, triglyceride; MVPA, moderate to vigorous physical activity in leisure.