Table 1.
Allelic frequencies of FPR1 SNPs and characteristics of patient population from Hôpital Cochin and Hôpital Européen George Pompidou
| FPR1 rs867228 | FPR1 rs5030880 | |||||
|---|---|---|---|---|---|---|
| Wild type (GG) n/tot (%) | Heterozygous (GT) n/tot (%) | Mutated Homozygous (TT) n/tot (%) | Wild type (TT) n/tot (%) | Heterozygous (TA) n/tot (%) | Mutated Homozygous (AA) n/tot (%) | |
| SNP frequency | 88/139 (63.3) | 42/139 (30.2) | 9/139 (6.5) | 114/140 (81.4) | 24/140 (17.1) | 2/140 (1.4) |
| Men | 55/91 (60.4) | 31/91 (34.1) | 5/91 (5.5) | 75/92 (81.5) | 15/92 (16.3) | 2/92 (2.2) |
| Women | 33/48 (68.8) | 11/48 (22.9) | 4/48 (8.3) | 39/48 (81.2) | 9/48 (18.8) | 0/48 (0) |
| Age ≤ 61 | 48/72 (66.7) | 21/72 (29.2) | 3/72 (4.2) | 58/72 (80.6) | 14/72 (19.4) | 0/72 (0) |
| Age > 61 | 40/67 (59.7) | 21/67 (31.3) | 6/67 (9) | 56/68 (82.4) | 10/68 (14.7) | 2/68 (2.9) |
| BMI ≤ 27.2 | 38/58 (65.5) | 17/58 (29.3) | 3/58 (5.2) | 51/59 (86.4) | 7/59 (11.9) | 1/59 (1.7) |
| BMI > 27.2 | 32/54 (59.3) |
18/54 (33.3) |
4/54 (7.4) |
52/64 (81.2) |
12/64 (18.8) |
0/64 (0) |
| Fever | 69/106 (65.1) |
31/106 (29.2) |
6/106 (5.7) |
90/107 (84.1) |
17/107 (15.9) |
0/107 (0) |
| No Fever | 19/33 (57.6) |
11/33 (33.3) |
3/33 (9.1) |
24/33 (72.7) |
7/33 (21.2) |
2/33 (9.1) |
| Cough | 60/98 (61.2) |
30/98 (30.6) |
8/98 (8.2) |
78/99 (78.8) |
19/99 (19.2) |
2/99 (2) |
| No Cough | 28/41 (68.3) |
12/41 (29.3) |
1/41 (2.4) |
36/41 (87.8) |
5/41 (12.2) |
0/41 (0) |
| Dyspnea | 66/105 (62.9) |
32/105 (30.5) |
7/105 (6.7) |
88/106 (83) |
16/106 (15.1) |
2/106 (1.9) |
| No Dyspnea | 21/33 (63.9) |
10/33 (30.3) |
2/33 (6.1) |
25/33 (75.8) |
8/33 (24.2) |
0/33 (0) |
| ICU ≤ 20 days | 18/28 (64.3) |
8/28 (28.6) |
2/28 (7.1) |
23/28 (82.1) |
4/28 (14.3) |
1/28 (3.6) |
| ICU > 20 days | 19/27 (70.4) |
6/27 (22.2) |
2/27 (7.4) |
20/27 (74.1) |
7/27 (25.9) |
0/27 (0) |
Abbreviations: BMI, body mass index; FPR1, formyl-peptide receptor 1; ICU, intensive care unit; SNP, single nucleotide polymorphism.
Abbreviations: CT, computed tomography; COVID-19, coronavirus disease 19; FPR1, formyl-peptide receptor 1; HEGP, Hôpital Européen George Pompidou; ICU, intensive care unit; PRR, pattern-recognition receptor; SNP, single nucleotide polymorphism;