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New potential targets of emerging anti-asthma therapies.
| New potential targets | New potential drugs | Molecular mechanisms of action | Effects in the control of severe asthma |
|---|---|---|---|
| TSLP | Tezepelumab | Prevention of TSLP binding to its receptor complex | ↓ Blood eosinophils ↓ FeNO ↓ Exacerbations ↑ FEV1 |
| IL-33 | REGN3500 | Prevention of IL-33 binding to ST2 receptor | ↑ Quality of life and symptom control |
| PGD2 | Fevipiprant | Selective antagonism of CRTH2 receptor | Weak FEV1 increase |
