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. 2020 Oct 1;111(12):4500–4509. doi: 10.1111/cas.14654

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© 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Correlation between fibroblast growth factor receptor2⁺ (FGFR2⁺) circulating tumor cells (CTCs) and FGFR2 FISH of gastric cancer patients. A, Representative picture of FGFR2 FISH. B, Correlation between immunohistochemistry (IHC) score and FGFR2 FISH. The FGFR2/CEN10 ratio was significantly correlated with the FGFR2 IHC score. C, Relationship between FGFR2⁺ CTCs by FACS and FGFR2 amplification by FISH. FGFR2⁺ CTCs were significantly correlated with the FGFR2/CEN10 ratio by Spearman's rank correlation test (r = .515, P = .002)