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The schematic depiction of the interplay between miRNAs and tumor-suppressive gene PTEN in renal cell cancer. MiR-22 and miR-203 are decreased, while miR-301 and miR-193a-3p are up-regulated in RCC. miRNA expression changes result in reducing the expression of PTEN. Consequently, cell proliferation, invasive behavior, and migration are enhanced in RCC.
