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Major checkpoint inhibition pathway in GBM cancer cells. MHC II, major histocompatibility complex II; TAA, tumor associated antigen; TCR, T cell receptor; MHCI, major histocompatibility complex I; PD-1, programmed cell death protein 1; PD-L1, programmed cell death ligand protein 1; TIM-3, T cell immunoglobulin mucin molecule 3; KIRs, killer immunoglobulin-like receptors.
