Table 1.
Half maximal inhibitory concentration (IC50) of LK-ME in the experiments performed in this study.
| LK-ME | Taxifolin | Quercetin | Luteolin | |
|---|---|---|---|---|
|
Biological activity | ||||
| NO production | ×1333.3 dil. | 123.8 μM | 6.9 μM | 4.6 μM |
| (7.7 μM) | ||||
| ROS production | ×41.5 dil | 239.5 μM | 28.4 μM | 36.3 μM |
| (247.1 μM) | ||||
| Lipid accumulation |
×319.5 dil. | 118.4 μM | 361.9 μM | 74.8 μM |
| (32.1 μM) |
||||
|
Cell cytotoxicity | ||||
| RAW264.7 cells (-LPS) | ×237.9 dil. | 360.5 μM | 54.7 μM | 20.6 μM |
| (43.1 μM) | ||||
| RAW264.7 cells (+LPS) | ×147.6 dil. | 358.4 μM | 101.3 μM | 25.7 μM |
| (69.5 μM) | ||||
| THP-1 cells (Macrophage differentiated) | n.d. | 662.9 μM | 124.5 μM | 31.5 μM |
| 3T3-L1 cells (Adipocyte differentiated) | ×73.5 dil. | 615.0 μM | 574.5 μM | 57.3 μM |
| (139.5 μM) | ||||
The taxifolin concentrations at the indicated dilution of LK-ME are given in parentheses. n.d.: not determined.