TABLE 1.
Analgesic mechanism of acetaminophen.
| Medicine | Target site | Effect/mechanism | References |
|---|---|---|---|
| Acetaminophen | COX-1, COX-2 | Inhibitory | Aminoshariae and Khan (2015) |
| Acetaminophen | COX-2 | Inhibitory | Graham et al. (2013) |
| Acetaminophen | COX-3 | Inhibitory | Chandrasekharan et al. (2002) |
| Acetaminophen | COX-3 | No clinically relevant effects | Graham and Scott (2005) |
| NAPQI | TRPA1 | Activating | Andersson et al. (2011) |
| Acetaminophen | TRPA1 | Activating | Gentry et al. (2015) |
| AM404 | Anandamide transport inhibitor, CB1 receptor | Re-uptake inhibitor, Activating | Beltramo et al. (1997) |
| AM404 | TRPV1 receptor | Activating | Zygmunt et al. (2000), Hogestatt et al. (2005), Roberts et al. (2002), Jennings et al. (2003), Mallet et al. (2010), Barrière et al. (2013), |
| AM404 | CB1 receptor, TRPV1 receptor | Activating | Rodella et al. (2005), Borsani et al. (2007) |
| AM404 | CB1 receptor, TRPV1 receptor | Not activating, Activating | Ohashi et al. (2017) |
| AM404 | CB1 receptor < TRPV1 receptor | Activating | Szallasi and Di Marzo (2000) |
| Acetaminophen | Opioids | Activating | Raffa et al. (2000), Raffa et al. (2004) |
| Acetaminophen | Serotonin | Increases content | Pini et al. (1996) |
| Acetaminophen | 5-HT3 receptor | Activating | Alloui et al. (2002), Pickering et al. (2006), Pickering et al. (2008) |
NAPQI, N-acetyl-p-benzoquinoneimine; AM404, N-acylphenolamine; COX, cyclooxygenase; TRPA1, transient receptor potential ankyrin 1; CB1, cannabinoid 1; TRPV1, transient receptor potential vanilloid 1.