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The ROS-responsive scaffold loaded with GEM and checkpoint inhibitor for chemoimmunotherapy. (A) ROS-degradable hydrogel scaffolds can achieve the co-delivery of GEM and aPDL1 into the tumor microenvironment for combination therapy. (B) The tumor growth curves of all groups. (C) The conditions of CD4+ and CD8+ T cell infiltration. Scale bar: 100 μm. (D) The numbers and ratios of immune cells in tumors under multiple treatments. Reproduced with permission from Wang C. et al. (2018).
