FIGURE 4.

Effect of linagliptin on in vivo mitochondrial respiration in treated mouse platelets. Platelets were obtained from mice after 7 days of treatment with linagliptin or vehicle. Platelets were assayed for oxygen consumption in an Oxygraph-2k high resolution respirometer. All data were expressed as the means ± SEM. n = 3/each group. Statistical comparisons were performed using the paired Student’s t-test. Data from graph are normally distributed according to Kolmogorov-Smirnov normality test. *p < 0.05 vs. vehicle. ETS, maximal electron transfer system capacity; ROX, residual oxygen concentration; LEAK, leak-state respiration (non-ADP-stimulated respiration); OXPHOS, oxidative phosphorylation capacity (ADP-stimulated respiration).