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Potential GLP-1-independent mechanism of DPP-4 inhibition by linagliptin in the regulation of platelet activation. cAMP is formed inside the mitochondrial matrix and stimulates the respiratory chain. The cAMP signals are terminated through degradation by PDE in the presence of linagliptin. cAMP, cyclic AMP; PDEs, phosphodiesterases; NO, nitric oxide.
