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PAGE analysis of glycosylase activities toward the lesion-containing 17-nt DNA duplexes oxoG/C and Tg/A (A) and quadruplex DNA Q4-oxoG and Q4-Tg (B). Comparison of the efficiency of cleavage of the tested substrates by DNA glycosylases (C). [Enzyme] = 2 μM, [DNA] = 1 μM, Ò = 25°C, and reaction time = 5 min for duplexes or 1 h for quadruplexes. Experiments were repeated twice. Representative gels are shown.
