Table 1.
Drugs | Clinic types of experiments | Types of psoriasis | Number of examinees | Usage time | Results | Refs. |
---|---|---|---|---|---|---|
Indigo naturalis oil extract | A non-controlled pilot study | Nail psoriasis | n = 28 | 24 weeks | The Nail Psoriasis Severity Index (NAPSI) decreased from 36.1 ± 14.7 to 14.9 ± 11.1, and the average Nasi score decreased from 11.7 ± 3.9 to 3.6 ± 3.2 | [82] |
Indigo naturalis ointment | A randomized, double-blind, placebo-controlled study | Moderate psoriasis |
n = 24 (drug:16, placebo: 8) |
8 weeks | In 56.3% of patients, the psoriasis area and severity index scores were improved by 75%, and IL-17 in skin genes of these patients was significantly down regulated compared with placebo | [83] |
Indigo naturalis ointment or vehicle ointment | A randomized, observer-blind, vehicle-controlled study | Recalcitrant psoriasis | n = 42 | 12 weeks | Compared with placebo, the scores of erythema, scale and lump and plaque area of indigo naturalis in treatment site were significantly reduced. The symptoms of psoriasis disappeared or nearly disappeared in 74% of patients with indigo naturalis | [81] |
Indigo naturalis composite ointment | – | Pediatric psoriasis | 8-year-old boy | 8 weeks | After treating with indigo naturalis composite ointment, the lesions of systemic psoriasis disappeared completely, and the affected body surface decreased from nearly 80–0%. Remission has lasted for over 2 years without any adverse reaction | [84] |
Indigo naturalis oil extract drops | – | Pediatric nail psoriasis with periodic pustular eruption | A 13-year-old girl | 6 months | After treat in one month, the pustulation of the nails and the crusted, keratotic erythematous lesions disappeared. A completely normal nail unit without Beau’s lines was achieved after 6 months without any adverse reaction Remission has lasted for over 1 year | [85] |