Table 4: Association of Frailty Index with incident MCR using Cox regression analysis.
All models below are adjusted for age, sex and education-years. Results are reported as Hazard ratios (HR) with 95% CI for each 0.01 Frailty Index increase.
| Model | Description | Events (MCR)/ Total participants |
HR | 95% CI | p-value |
|---|---|---|---|---|---|
| 1 | Adjusted for age, sex and education-years. | 68/551 | 1.07 | 1.03-1.11 | <0.001 |
| 2 | FI redefined excluding mobility related items. | 68/551 | 1.07 | 1.03-1.10 | <0.001 |
| 3 | Excluded participants who died before MCR. | 68/534 | 1.07 | 1.03-1.11 | <0.001 |
| 4 | Adjusted for cognitive scores. | 67/542 | 1.06 | 1.03-1.10 | 0.001 |
| 5 | MCI free model. | 57/514 | 1.06 | 1.02-1.10 | 0.004 |
| 6 | Excluded participants who developed incident MCR in the first two years of follow-up | 40/520 | 1.05 | 1.00-1.10 | 0.035 |
| 7 | Adjusted for social vulnerability index score. | 68/550 | 1.06 | 1.02-1.10 | 0.003 |
| 8 | FI redefined excluding chronic illness items. | 68/540 | 1.06 | 1.02-1.09 | 0.002 |