Table 2.
Laboratory parameters of COVID‐19 patients
| Reference |
COVID‐19 Moderate (n = 11) Median peak (range) |
COVID‐19 Severe (n = 12) Median peak (range) |
P‐value | |
|---|---|---|---|---|
| Before study sampling | ||||
| C‐reactive protein, mg L−1 | < 3 | 176 (34–346) | 310 (124–452) | 0.0268 |
| Procalcitonin, μg L−1 | < 0.5 | 0.4 (0.11–66) | 1.2 (0.19–10) | 0.1335 |
| D‐dimer, mg L−1 | < 0.56 | 0.88 (0.33–1.5) | 2.5 (0.9–5.4) | < 0.0001 |
| Ferritin, μg L−1 | 10–150 | 866 (222–2293) | 1946 (305–5500) | 0.0156 |
| Fibrinogen, g L−1 | 2–4.2 | 6.1 (4.9–10.2), n = 8 n/a | 7.2 (4.1–9.6) | 0.8066 |
| Lactate dehydrogenase, μkat L−1 | < 3.5 | 5.7 (0.89–13.7) | 10.9 (7–23) | 0.0002 |
| Alanine aminotransferase, μkat L−1 | < 0.76 | 0.8 (0.51–3.43) | 1.31 (0.67–2.52) | 0.3788 |
| Bilirubin, μmol L−1 | < 26 | 8 (4–15) | 12 (7–81) | 0.0063 |
| Creatinine, μmol L−1 | < 90 | 77 (46–96) | 87 (54–326) | 0.0938 |
| Prothrombin complex, INR | < 1.2 | 1 (0.9–1.1) | 1.1 (1–1.4) | 0.0077 |
| Troponin T, ng L−1 | < 15 | 9.5 (5–19), n = 1 n/a | 19 (5–601) | 0.0159 |
| Myoglobin, μg L−1 | < 73 | 36.5 (22–158), n = 5 n/a | 658 (46–6400) | 0.0008 |
| Lymphocytes, lowest, × 109 L−1 | 1.1–3.5 | 0.7 (0.3–1.9) | 0.5 (0.2–1.1) | 0.1443 |
| Neutrophils, lowest, × 109 L−1 | 1.6–5.9 | 3.7 (0.5–6.5) | 6.3 (3.3–15.9) | 0.0195 |
| Platelets, lowest, × 109 L−1 | 165–387 | 228 (131–342) | 212 (115–315) | 0.7980 |
| Platelets, highest, × 109 L−1 | 165–387 | 401 (152–659) | 427.5 (214–770) | 0.7399 |
| At study sampling (± 24 h) | ||||
| C‐reactive protein, mg L−1 | < 3 | 103 (20–394), n = 1 n/a | 258 (51–346) | 0.0249 |
| Procalcitonin, μg L−1 | < 0.5 | 0.36 (0.12–866), n = 2 n/a | 0.945 (0.16–10) | 0.3358 |
| D‐dimer, mg L−1 | < 0.56 | 0.60 (0.36–1.56), n = 1 n/a | 3.7 (0.74–7.6) | 0.0002 |
| Ferritin, μg L−1 | 10–150 | 847 (161–2370) | 1852 (312–4306), n = 1 n/a | 0.0336 |
| Fibrinogen, g L−1 | 2–4.2 | 4.9 (4.7–10.2), n = 8 n/a | 7.4 (4.1–9.6), n = 1 n/a | 0.6786 |
| Bilirubin, μmol L−1 | < 26 | 6 (0–11) | 9 (6–81) | 0.0011 |
| Creatinine, μmol L−1 | < 90 | 69 (36–78) | 73.5 (44–326) | 0.2536 |
| Haemoglobin, g L−1 | 117–153 | 118 (90–145) | 112.5 (84–146) | 0.5553 |
| P‐Albumin, g L−1 | 36–48 | 27 (21–37), n = 4 n/a | 18 (16–22) | 0.0188 |
| Prothrombin complex, INR | < 1.2 | 1.05 (0.9–1.1), n = 5 n/a | 1.1 (0.9–1.4) | 0.0980 |
| Troponin T, ng L−1 | < 15 | 7.5 (5–10), n = 3 n/a | 17.5 (5–434) | 0.0325 |
| Lymphocytes, lowest, × 109 L−1 | 1.1–3.5 | 1.3 (0.3–2.4) | 0.65 (0.3–1.8) | 0.0231 |
| Neutrophils, highest, × 109 L−1 | 1.6–5.9 | 4.6 (0.9–9.3) | 11.2 (8.5–16.7) | < 0.0001 |
| Platelets, lowest, × 109 L−1 | 165–387 | 345.5 (131–642), n = 1 n/a | 363 (179–502) | 0.9876 |
| Leukocytes, highest, × 109 L−1 | 3.5–8.8 | 7.1 (1.5–12.6) | 12.6 (9.2–18.4) | 0.0001 |
| Leukocytes, lowest, × 109 L−1 | 3.5–8.8 | 6.7 (1–10.5) | 9.8 (7.6–15.7) | 0.0003 |
| At study sampling (± 5 days) | ||||
| Interleukin‐6, ng L−1 | < 7 | 62 (2–150), n = 2 n/a | 472.5 (33–8093) | 0.0035 |
P‐value: Mann–Whitney U‐test, n/a: not available.
The bold values indicate statistical significance according to the following: *P < 0.05, **P < 0.01, ***P < 0.001.