Figure 10.

Dose–response curves of sulfur–diazocine-functionalized axitinib derivatives 5 and 6 in an in vitro VEGFR-2 kinase assay with and without irradiation. Data points are means of double determinations with their standard deviation as error bars. Final DMSO concentration 10%. (a) Z-5 in the dark (red, IC₅₀ > 10,000 nM) as well as after irradiation at 405 nm (blue, IC₅₀ = 214 nM, residual activity (plateau): 6%, R² = 0.94). (b) Z-6 in the dark (red, IC₅₀ > 10,000 nM) as well as after irradiation at 405 nm (blue, IC₅₀ = 251 nM, residual activity (plateau): 10%, R² = 0.94).