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Kinome activity profiling of treated human umbilical vein endothelial cell (HUVEC) cell lysate. Heat map shows the phosphorylation degree of affected peptides from red (high phosphorylation degree) to blue (low phosphorylation degree). A lower phosphorylation degree confirms more inhibited protein kinases. Lysates were treated with 20 µM diazocine-functionalized axitinib derivative 5 with or without irradiation at 405 nm, 1 µM axitinib or 10% DMSO as negative control.
