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. 2020 Dec;190(12):2355–2375. doi: 10.1016/j.ajpath.2020.08.018

Figure 1.

Figure 1

Time course of lymphatic growth in lungs after bleomycin injury. A–C: Lung panoramas made from tiled low-magnification fluorescence images of sections (200-μm thick) of left lungs of C57BL/6 prospero homeobox 1-enhanced green fluorescent protein (Prox1-EGFP) mice after a single dose of bleomycin. Compared with the control lung (A), lymphatics are larger and more numerous around major airways and blood vessels and in the lung parenchyma at 14 days after bleomycin administration (B). Lymphatics are less numerous at 56 days (C). D–F: Enlargements of regions in A–C. Enlargement of collecting lymphatics (arrows) around bronchus and pulmonary vein. G–I: Abundance of lymphatics (area densities) in whole lung, hilum, and parenchyma. Dots represent individual mice. n = 4 to 8 mice per group (G–I). ∗P < 0.05 versus day 0 (analysis of variance). Scale bars: 1 mm (A–C); 500 μm (D–F).