Figure 4.
In vivo PK/PD of 24 showing (a) pIRAK1 modulation and (b) plasma–tumor exposures. Mean mPPB of 24 = 92.8% (Average of 2 determinations). Unbound plasma exposures at 12 and 24 h estimated to be 868.0 and 49.3 ng/mL, respectively.
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