Table 7. Mean Plasma and Tumor Concentrations of Compound 24 after Repeated Oral Administration in OCI-Ly3 Tumor Bearing Mice.
Treatment groups | Mean plasma conc (ng/mL) | Mean tumor conc (ng/g) |
---|---|---|
25 mg/kg | 5077.8 ± 587.5 | 2667.2 ± 399.7 |
50 mg/kg | 11565.9 ± 1074.7 | 8291.2 ± 1013.3 |
100 mg/kg | 23268.2 ± 2280.2 | 17943.3 ± 2122.6 |
200 mg/kg | 39123.0 ± 3101.2 | 36973.7 ± 2622.5 |