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. 2020 Dec 14;17:152. doi: 10.1186/s12966-020-01057-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Associations between intervention-induced change and fasting baseline variables. Panels A-C represent the curvilinear relationships between intervention-induced change in insulin tAUC and HOMA2-IR, insulin tAUC and HOMA2-%β, triglyceride tAUC and fasting triglycerides, respectively. Fasting baseline variables were taken as the average across three conditions. The curved black line represents the line of best fit, calculated from a mixed model controlling for age, sex, waist circumference, change in plasma volume, testing site and treatment order. The shaded area represents the 95% confidence bands; ln indicates natural logarithm