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. 2020 Dec 14;13:169. doi: 10.1186/s13041-020-00709-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — AJ disruption enhanced non-vertical cleavage plane orientation. a Cortical sections immunolabeled for N-cadherin (red) to label neuroepithelial cells and counterstained with TO-PRO-3 (blue) to label nuclei following 2 mM EGTA treatment. E13.5 cortical hemispheres were exposed to control or 2 mM EGTA-containing medium for 10 min. EGTA-treatment disrupted N-cadherin structure at the apical side (arrows). Nuclei were counterstained with TO-PRO 3. Representative images, analyzed by confocal microscopy, of 3 paired cortices are shown. CP, cortical plate; VZ, ventricular zone; V, ventricle; scale bar, 10 µm. b Percentage of apical mitotic cells with a non-vertical cleavage plane. Data represent mean + S.E.M. (n = 3–4, *P = 0.0235, unpaired t tests)