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. 2020 Dec 14;39:282. doi: 10.1186/s13046-020-01761-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The level of miR-146a-5p significantly decreased in the exosomes isolated from CAFs after ADT. a Heatmap of the significantly differential miRNAs between ETOH-treated and matched DHT-treated CAFs-derived exosomes. Red, green, and black indicated miRNAs with higher, lower, and equal expression, respectively. b The scatter plot represents the differential miRNA expression profiles between ETOH-treated and DHT-treated CAFs-derived exosomes. Red, green, and purple indicated miRNAs with higher, lower, and equal expression, respectively. c Volcano plot presents differential expression of miRNAs between ETOH-treated and matched DHT-treated CAFs-derived exosomes. Red, green, and purple indicated miRNAs with higher, lower, and equal expression, respectively. d Real-time PCR analysis of miR-146a-5p expression in exosomes from DHT-treated CAFs and matched ETOH-treated CAFs (n = 4). e Real-time PCR analysis showing the expression of miR-146a-5p in DHT-treated CAFs and matched ETOH-treated CAFs (n = 4). Data are shown as mean ± SD representing triplicate measurements. (Student’s t-test, **P < .01, ***P < .001, ****P < .0001)