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. 2020 Dec 14;39:282. doi: 10.1186/s13046-020-01761-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MiR-146a-5p impairs cell migration and invasion by inhibiting EMT in PCa cells in vitro. a and b The effect of miR-146a-5p on the migration and invasion of LNcaP cells was assessed by a Transwell assay (scale bars = 25 μm). c and d The effect of miR-146a-5p on the migration and invasion of DU145 cells was assessed by a Transwell assay (scale bars = 25 μm). e and f The effect of miR-146a-5p on the RNA levels of EMT markers and MMPs in LNcaP and DU145 cells. g and h The effect of miR-146a-5p on the protein levels of EMT markers and MMPs in LNcaP were determined by western blot and densitometric quantification. i and j The effect of miR-146a-5p on the protein levels of EMT markers and MMPs in DU145 were determined by western blot and densitometric quantification. Data are shown as mean ± SD representing triplicate measurements. (Student’s t-test, ***P < .001, ****P < .0001)