Table 4. Antibacterial Activity of Selected Compounds.
| MIC
(μM)a |
||||||
|---|---|---|---|---|---|---|
| Cmpd | E. coli (ATCC 25922) | S. aureus (ATCC 29213) | E. faecalis (ATCC 29212) | P. aeruginosa (ATCC 27853) | E. coli (JD17464)b | E. coli (JW5503)c |
| 4a, 4b, 5a, 5b, 9a, 9c, 10, 14, 15c, 15d | >50 μM | >50 μM | >50 μM | >50 μM | >50 μM | >50 μM |
| 9b | >50 μM | >50 μM | >50 μM | >50 μM | >50 μM | 1.56 μM |
| 13 | >50 μM | >50 μM | >50 μM | >50 μM | >50 μM | 50 μM |
| 15a | >50 μM | >50 μM | 3.13 μM | >50 μM | >50 μM | 0.78 μM |
| 15b | >50 μM | >50 μM | >50 μM | >50 μM | >50 μM | 1.56 μM |
| 15e | >50 μM | >50 μM | 3.13 μM | >50 μM | >50 μM | 0.78 μM |
| 16a | >50 μM | >50 μM | 12.5 μM. | >50 μM | >50 μM | 12.5 μM |
| 16b | >50 μM | 25 μM | 6.25 μM | >50 μM | >50 μM | 3.13 μM |
| ciprofloxacin | 0.05 μM | 1.51 μM | 3.02 μM | 3.02 μM | 0.121 μM | 0.015 μM |
a
MIC (minimum inhibitory concentration that inhibits the growth of bacteria by ≥90%) values against E. coli and S. aureus.
b
E. coli strain with impaired outer membrane, lpxC deletion mutant.
c
E. coli strain with defective efflux pump, tolC deletion mutant.