Table 1. Structure Activity Relationships (SARs) of C2 (Hetero)aryl Analogues.
Firefly luciferase reporter gene assay reported as EC50 ± SD (μM) of 3 biological replicates (3 technical replicates per experiment).
Firefly luciferase enzymatic assay reported as IC50 ± SD (μM) of 2 biological replicates (3 technical replicates per experiment).
logD is calculated with the shaking flask method at pH = 7.4 from the partition between n-octanol/water.
Reference: Tetrahedron2020, 76, 130819.
IA, inactive.
ND, not determined.