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. 2020 Nov 4;11(12):2421–2427. doi: 10.1021/acsmedchemlett.0c00405

Table 1. Structure Activity Relationships (SARs) of C2 (Hetero)aryl Analogues.

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a

Firefly luciferase reporter gene assay reported as EC50 ± SD (μM) of 3 biological replicates (3 technical replicates per experiment).

b

Firefly luciferase enzymatic assay reported as IC50 ± SD (μM) of 2 biological replicates (3 technical replicates per experiment).

c

logD is calculated with the shaking flask method at pH = 7.4 from the partition between n-octanol/water.

d

Reference: Tetrahedron2020, 76, 130819.

e

IA, inactive.

f

ND, not determined.