Table 2. Structure Property Relationships (SPR) of the Synthesized Analogues.

			Caco-2c		mHep Stability
#	Sola	mPPBb	A-B	B-A	Clintd	T1/2e
2	468	97	18.0	16.4	11.9	58
3	378	95	18.0	15.7	9.12	76
14	>250	97	16.2	11.2	>250	<3
15	>250	94	14.2	10.1	34.5	20
46	530	98			8.99	77
16	518	97			53.0	13
17	>250	96	15.7	12.6	>250	<3
18	366	97	18.8	15.7	>250	<3
19	576	98	12.7	11.7	4.49	154
20	733	86	22.3	20.6	<2.89	>240
21	477	75			<2.89	>240
22	440	74			<2.89	>240
23	469	97	12.3	11.5	18.2	38
24	574	98	17.2	16.2	4.49	154
25	834	93	21.8	16.9	<2.89	>240
26	603	80			<2.89	>240
27	487	77			<2.89	>240
47	265		13.3	10.7	12.4	56
48			13.3	9.37	54.4	13
49			12.3	11.0	<2.89	>240
50	854	89			184	4
51	446	97			>250	<3
52	556	96			8.77	79
53	8.4	96	18.1	15.9	19.0	37
54	699	76			142	5

^aAqueous kinetic solubility (μM).

^bmPPB, murine plasma protein binding (% bound).

^cCaco-2 permeability assay (P_app (10^–6 cm/s)).

^dMurine hepatocyte intrinsic clearance (μL/min/10⁶ cells).

^eMurine hepatocyte half-life (min).