Table 3. Cytotoxicity of Selected Compounds in HepG2 Cells.

#	ClogPa	TPSAa	IC50(μM)
2	4.43	62	58.4
3(e2)b	3.68	62	200
20	3.10	84	200
24	5.35	81	68.9
47	3.51	71	200
49	3.48	75	200
55c	5.19	62	0.02
56c	4.96	62	13.3
57c	5.30	62	5.04

^aGenerated with OSIRIS Datawarrior version 5.0.0 © 2002–2019 Idorsia Pharmaceuticals Ltd.

^bCpd 27e2 in our previous work.¹⁸

^cCpds 55–57 are reported in our previous work¹⁸ and are esters of 2 with isopropanol, cyclopropanol, and cyclobutanol, respectively.