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. 2020 Dec 14;13:168. doi: 10.1186/s13041-020-00707-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — In contrast to Itgb3^fl/fl;GFP/Cre⁺ neurons, tangential cortical positions of C57;GFP/Cre⁺ layer II/III neurons are correlated with dendritic complexity. a 3D schematic showing cortical (x,y) positions of neurons in (b) over a dorsal view of the mouse brain. The x-axis measures distance away from the splenium of the corpus callosum (positive numbers are rostral), and the y-axis measures distance away from the midline. b Cortical (x,y) positions of C57;GFP/Cre⁺ neurons. c Cortical (x,y) positions of Itgb3^fl/fl;GFP/Cre⁺ neurons. d Total dendritic length is significantly correlated to cortical position along a tangential gradient among layer II/III C57;GFP/Cre⁺ neurons, but not among Itgb3^fl/fl;GFP/Cre⁺ neurons (linear regression; respective regression slopes are significantly different). e Total basal dendritic length, f number of basal bifurcations, and g number of basal tips are all correlated to cortical position along a tangential gradient among C57;GFP/Cre⁺ but not Itgb3^fl/fl;GFP/Cre⁺ neurons. In each graph, the linear regression slopes between C57;GFP/Cre⁺ and Itgb3^fl/fl;GFP/Cre⁺ are significantly different. R² and p-values for (g–j) are summarized in Table 1. C57;GFP/Cre⁺ neurons were previously reported in Holley et al. [31] and re-analyzed for this study. 3D model of mouse brain

© 2017 Allen Institute for Brain Science, Allen Mouse Common Coordinate Framework (CCFv3) [78]. Available from: atlas.brain-map.org. C57;GFP/Cre⁺ N = 116 neurons; Itgb3^fl/fl;GFP/Cre⁺ N = 86 neurons