Table 4. PK Profile of Compound 18 in BALB/c Mice^a.

route	IVb	POc
dose (mg/kg)	2	4
Cmax (μM)		2.2 ± 0.6
C24h (μM)		0.62 ± 0.21
Tmax (h)		4.3 ± 2.3
AUC72h (μM-h)	23.0	43.9
AUCtot (μM-h)	23.7	44.4
T1/2 (h)	15
CL (mL/min/kg)	2.0
Vss (L/kg)	2.7
F (%)		94

^a12 time points, 3 mice/time point/route.

^bSolution vehicle: 2.5% NMP; 67.5% PEG 400; 4.5% Pluronic F-68; 25.5% water.

^cSolution vehicle: 5% NMP; 76% PEG 400; 19% TPGS.