Table 5. Exposure of Compound 18 following Dosing Prodrug 19 in Mouse Acanthosis.

dose (mg/kg QD)a	5	15	45
day 1 AUCtot (μM-h)	13.9	30.9	274.3
day 9 AUC24 (μM-h)	9.0	45.2	162.9
day 9 Cmax (μM)	0.65 ± 0.19	2.58 ± 0.36	8.34 ± 2.26
day 1 C24h (μM)	0.21 ± 0.08	0.48 ± 0.14	0.91 ± 0.33
day 9 C24h (μM)	0.15 ± 0.08	1.36 ± 0.56	5.82 ± 1.10
day 9 C24h fold mouse Th17 IC90b	0.4×	3.2×	13.9×

^aProdrug was dosed to provide the indicated amount of parent after phosphate hydrolysis; solution vehicle: 20% of 0.1 M acetate buffer; 80% PEG 400.

^bProtein binding adjusted mouse Th17 IC₉₀ = 0.42 μM