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. 2020 Nov 24;10:531344. doi: 10.3389/fonc.2020.531344

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Copyright © 2020 Dale, Molinelli, Vischioni, Vitolo, Bonora, Magro, Mairani, Hasegawa, Ohno, Dahl, Valvo and Fossati

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brainstem DVHs in relative (A, C) and absolute volume (≤2 cm³) (B, D) of 30 patients treated at CNAO, presented in D _{LEM I} (A, B) and D _MKM (C, D). Crosses represent the former CNAO and NIRS dose constraint of D _1% ≤30 Gy (RBE). Triangles represent the new D _MKM constraints V _{40 Gy (RBE)} <0.1 cm³ and V _{30 Gy (RBE)} <0.7 cm³ as defined by Shirai et al. (14). Squares in (B) represent the possible new D _{LEM I} constraints (error bars, 95% CI) resulting from the dose translation model presented in this work, see Figure 3 .