Figure 5.

Absolute volume DVH showing old CNAO D _{LEM I|1%} <30 Gy (RBE) constraint (cross) and the translated Shirai constraints D _{LEM I|0.7 cm³} <41 Gy (RBE) and D _{LEM I|0.1 cm³} <49 Gy (RBE) (squares, error bars = 95% CI), converted into EQD2 (assuming α/β ratio = 2 Gy) in comparison with the EQD2 constraints applied at HIT as reported by Nikoghosyan et al. (21): D _{LEM I|1%} <54 Gy (RBE) and D _{LEM I|max} <60 Gy (RBE) (circles). As an approximation to the absolute volume relating to the D _1% constraints, the median brainstem volume in our data set (26 cm³) was used. The translated constraints are more closely related to the constraints used at HIT than the old CNAO constraint.