Table 1:
Clinical and laboratory findings
| Data Variable | C3G with monoclonal Ig n=36 |
C3G without monoclonal Ig n=59 |
|---|---|---|
| Age at diagnosis (years) | Median: 60 | Median: 28 |
| Range: 20-85 | Range: 4-84 | |
| Sex (M/F) | Male: 25 (69.4%) | Male: 28 (47.5%) |
| Female: 11 (30.6%) | Female: 31 (52.5%) | |
| Race | White: 30 (83.3%) | White: 46 (78.0%) |
| Black: 2 (5.6%) | Black: 1 (1.7%) | |
| Asian: 0 | Asian: 2 (3.4%) | |
| American Indian/Alaskan Native: 1 (2.8%) | American Indian/Alaskan Native: 0 | |
| Other: 1(2.8%) | Other: 3 (5.1%) | |
| Unknown: 2 (5.6%) | Unknown: 7 (11.9%) | |
| Ethnicity | Hispanic or Latino: 1 (2.8%) | Hispanic or Latino: 0 |
| Non-Hispanic or Latino: 30 (83.3%) | Non-Hispanic or Latino: 51(86.4%) | |
| Unknown: 5 (13.9%) | Unknown: 8 (13.6%) | |
| Blood Urea Nitrogen (mg/dL) | Median: 37.5 | Median: 18 |
| Range: 15-95.8 | Range: 5.5-72 | |
| Serum Creatinine (mg/dL) at diagnosis | Median: 1.9 | Median: 1.3 |
| Range: 0.8-14.7 | Range: 0.3-7.9 | |
| Serum albumin at diagnosis (g/dL) | Median: 3.3 | Median: 3.5 |
| Range: 2.4-4.6 | Range: 1.2-4.5 | |
| Hematuria | Positive: 32 (88.9%) | Positive: 51 (86.4%) |
| Negative: 4 (11.1%) | Negative: 8 (13.6%) | |
| Proteinuria (g/24 hours) | Median: 3.0 | Median: 1.7 |
| Range: 0.2-15.0 | Range: 0.3-24.2 | |
| Immunology | ||
| Anti-GBM antibody | Positive: 0; Negative: 16; NA: 20 | Positive: 1*; Negative: 21; NA: 37 |
| ANCA/PR-3/MPO | Positive: 1; Negative: 23; NA: 12 | Positive: 0; Negative: 46; NA: 13 |
| Anti-streptolysin | Positive: 0; Negative: 6; NA: 30 | Positive: 2; Negative: 15; NA: 42 |
| Anti-DNase B | Positive:0; Negative: 4; NA: 32 | Positive: 0, Negative: 6; NA: 53 |
| ANA | Positive: 4; Negative: 24; NA: 8 | Positive:7; Negative: 50; NA: 2 |
| Anti-ds DNA | Positive: 1; Negative: 17; NA: 18 | Positive: 4; Negative: 43; NA: 12 |
| Cryoglobulins | Positive: 2#; Negative: 19; NA: 15 | Positive: 1@; Negative: 36; NA:22 |
| Cryofibrinogen | Positive: 0; Negative: 21; NA: 15 | Positive: 0; Negative: 35; NA: 24 |
| Complement | ||
| C3 | Low: 12; Normal: 23; NA: 1 | Low: 28; Normal: 30; NA: 1 |
| C4 | Low: 4; Normal: 31; NA: 1 | Low: 7; Normal: 49; NA: 3 |
Abbreviations: ANA: antinuclear antibody, ANCA, anti-neutrophil cytoplasmic antibodies; GBM, glomerular basement membrane; NA, not available; PR-3, anti-proteinase antibodies; MPO, anti-myeloperoxidase antibodies
*
Anti-GBM antibody: 6.6 EU/mL (results up to 50 EU/mL may occur in patients without anti-GBM disease and considered as equivocal).
@
Type 3 cryoglobulinemia
#
Type 1/Type 2 cryoglobulinemia